منابع مشابه
Modular assembly of yeast mitochondrial ATP synthase.
The mitochondrial ATP synthase (F(1)-F(0) complex) of Saccharomces cerevisiae is a composite of different structural and functional units that jointly couple ATP synthesis and hydrolysis to proton transfer across the inner membrane. In organello, pulse labelling and pulse-chase experiments have enabled us to track the mitochondrially encoded Atp6p, Atp8p and Atp9p subunits of F(0) and to identi...
متن کاملimide-reactive proteolipid of mitochondrial ATP synthase
Ian M. FEARNLEY,* John E. WALKER,*§ Ryan D. MARTINUS,t Robert D. JOLLY,t K. Brett KIRKLAND,t G. John SHAWI and David N. PALMERt * M.R.C. Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, U.K., t Department of Veterinary Pathology and Public Health, Massey University, Palmerston North, New Zealand, and t Biotechnology Division, Department of Scientific and Industrial Research, Palm...
متن کاملATP Synthase Diseases of Mitochondrial Genetic Origin
1 Institut de Biochimie et Génétique Cellulaires, Centre National de la Recherche Scientifique UMR 5095, Université de Bordeaux, Bordeaux, France, 2 Department of Life Sciences, Imperial College London, London, United Kingdom, 3 Department of Structural Biology, Max-Planck-Institute of Biophysics, Frankfurt, Germany, 4 Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw...
متن کاملNuclear genetic defects of mitochondrial ATP synthase.
Disorders of ATP synthase, the key enzyme of mitochondrial energy provision belong to the most severe metabolic diseases presenting as early-onset mitochondrial encephalo-cardiomyopathies. Up to now, mutations in four nuclear genes were associated with isolated deficiency of ATP synthase. Two of them, ATP5A1 and ATP5E encode enzyme's structural subunits alpha and epsilon, respectively, while th...
متن کاملGenes for bacterial and mitochondrial ATP synthase.
The structures of the ATP synthases in bacteria and mitochondria are very similar (for reviews see Senior, 1979; Fillingame, 1981 ; Racker, 1981 ; Walker et al., 1982). They are membrane-bound enzymes composed of two distinct domains: a domain called F, which is buried in the membrane and attached to it a domain known as F, which lies outside the membrane (see Fig. 1). F, is composed of five di...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2018
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1801697115